Treatments for Idiopathic Multicentric CD

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The reference treatment involves an antibody (immunotherapy) which neutralizes the effect of the IL-6.

Two antibodies may be used subject to availability: siltuximab (Sylvant®) and tocilizumab (RoActemra®). This treatment is suspensive and its duration is therefore indeterminate. It produces rapid effects but relapse is common if the treatment is withdrawn.

Corticosteroids or another antibody, rituximab (Mabthera®) may be used to treat less severe forms.



The prognosis has improved significantly since the introduction of these new treatments but serious, resistant, life-threatening forms still exist.