Treatments for HHV8 + Multicentric CD and HIV

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The reference treatment involves an antibody (immunotherapy) which destroys the cells (B lymphocytes) which contain the HHV-8 virus. The antibody used is rituximab (Mabthera®). It is often associated with treatment with etoposide (vepeside®, celltop®) in an emergency, which quickly brings the symptoms under control.

An effective antiretroviral treatment is essential in order to obtain and maintain a good response to the treatment.

Relapse is possible but the disease generally responds to a second treatment.


The prognosis has improved significantly since the introduction of these new treatments.
There is a risk of the disease developing into a malignant lymph node tumour (lymphoma), but this risk has been significantly reduced since the introduction of rituximab®.